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Post subject: Venlafaxine (Effexor)
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An excellent website: http://www.mentalhealth.com/drug/p30-e02.html
http://www.remedyfind.com/rem.asp?ID=13495
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Effexor etc. (Venlafaxine) is a member of a new class of antidepressants called "selective serotonin and norepinephrine reuptake inhibitors" (SSNRI's). Cymbalta etc. (Duloxetine), approved in 2004 (U.S. FDA; European Union) is the other antidepressant in the SSNRI class. Unlike “selective serotonin reuptake inhibitors” (SSRI’s) such as Prozac (Fluoxetine), Paxil (Paroxetine) etc., which only balance levels of the nerve transmitter serotonin, SSNRI’s have the ability to affect two neurotransmitters - serotonin and norepinephrine.
Venlafaxine has acquired a reputation for being one of, if not the single-most, difficult antidepressant to discontinue. Withdrawal side-effects may include: sensory disturbances including shock-like electrical sensations (called “brain shivers” or “brain zaps”); depression; fatigue; nausea; dizziness; headache; insomnia; and anxiety. The cause of these side effects is believed to be caused by Venlafaxine’s unique pharmacokinetic makeup. In order to produce its effect upon two neurotransmitters, serotonin and norepinephrine, Venlafaxine also contains an active metabolite called O-desmethylvenlafaxine (ODV). Both Venlafaxine and ODV have very short half-lives (the amount of time before half of the drug's peak plasma level is eliminated by the body). Venlafaxine's half life is 4 hours. Its primary metabolite, O-desmethylvenlafaxine (ODV) has a half life of 10 hours. In comparison, an SSRI like Prozac (Fluoxetine) has a half-life of 2-3 days. Because of this short half-life, Venlafaxine withdrawal symptoms can occur as quickly as with one missed, or delayed, dose.
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I'm still looking for the site that told me of the dependancy, I'll add it when I find it.
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 Thu May 25, 2006 10:37 am |
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According to this I shouldn't even have been prescribed it with two failed suicide attempts on record... And what "special monitoring"?!? 
http://www.drugs.com/mtm/venlafaxine.html
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What should I discuss with my healthcare provider before taking venlafaxine?
• Before taking venlafaxine, tell your doctor if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), selegeline (Eldepryl), or tranylcypromine (Parnate) during the last 14 days. Serious and sometimes fatal reactions have occurred when these medicines were taken at the same time and they must not be used together with venlafaxine.
• Before taking venlafaxine, tell your doctor if you have:
· liver disease,
· kidney disease,
· high blood pressure,
· seizures or epilepsy,
· bipolar disorder (manic depression),
· family history of bipolar disorder or suicide, or
· suicidal thoughts.
• If you have any of the conditions listed above, you may not be able to take venlafaxine, or you may need a dosage adjustment or special monitoring during treatment.
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_________________
Why try so hard to fit in when you were born to stand out?
Go on - CLICK ME - you know you want to! |
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| Fri May 26, 2006 10:07 am |
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my doctor wants to put me on that, but after reading this, i'm not so sure... i have suicidal thoughts on almost a daily basis, and i'm not sure if effexor would help that lol. plus, i don't want to have that dependency issue, as i sometimes forget to take a dose of my medication. i also don't want something i'll never be able to stop taking. freaky drugs, i tell ya.
_________________
"The true mystery of the world is the visible, not the invisible" -Oscar Wilde
7/22/04 |
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| Fri May 26, 2006 11:06 am |
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Dude, listen to this list of drugs:
300mg Effexor
300mg Welbutrine
350mg Soma (3x day)
1mg Klonopin (3x day)
2mg Klonopin at bedtime
20mg Ambien at bed time
And guess what, they really don't work too good.
But... Those are to "relieve" the symptoms of DID, I do assloads of therapy at home (and when I was in the hospital) and I am about to go see a Clinical Hypnotherapist person (try to bring out memories, but I'm afraid of false memories) and I'll be seeing another therapist besides that one. I say fuk the shrinks, I'll get my drugs from a General Practicioner and make my progress with the therapists.
I read somewere in this forum that Effexor is a relatively cheap drug, dear gods it's really not. It costs me soooooo much.
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| Fri Aug 18, 2006 1:05 am |
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